Drug Dev Ind Pharm. 2003 Apr;29(4):475-87.

Adsorption of an amine drug onto microcrystalline cellulose and silicified microcrystalline cellulose samples.

Steele DF, Edge S, Tobyn MJ, Moreton RC, Staniforth JN.

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Pharmaceutical Technology Research Group, Department of Pharmacy & Pharmacology, University of Bath, Bath, UK. d.f.steele@bath.ac.uk

Abstract

The adsorption of a model amine drug (tacrine hydrochloride) from aqueous solution onto 21 microcrystalline cellulose (MCC) based samples has been investigated. The MCC source (manufacturer) affected adsorption. The adsorption appeared to be fully reversible. Adsorption was reduced by the use of high-density grade MCC, high-energy milling, and silicification. Adsorption of the model drug was not affected by the particle size of the MCC. Significant variations of the adsorption characteristics between batches of certain MCC products were found. The primary mode of adsorption was by ion exchange.

PMID:: 12737540; [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

Surface energy of microcrystalline cellulose determined by capillary intrusion and inverse gas chromatography. [AAPS J. 2008]
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