Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
J Rheumatol. 2003 May;30(5):1112-4.

Deriving an operational definition of low disease activity state in rheumatoid arthritis.

Author information

  • 1VU University Medical Centre, Amsterdam, The Netherlands. m.boers@azvu.nl


This article summarizes the process proposed to come to a definition of low disease activity in rheumatoid arthritis (RA). The purpose of this definition is to aid the interpretation of trial and longitudinal study results. A conceptual proposal is "a disease activity state that is deemed a useful treatment target by both physicians and patients." An operant definition can be derived by judgmental (opinion-based) or statistical (data-based) approaches, but the first seems more appropriate. Once a few candidate definitions have been selected, their usefulness and prognostic validity can be tested in longitudinal datasets.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk