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Genome Biol. 2003;4(5):R32. Epub 2003 Apr 30.

Combined histomorphometric and gene-expression profiling applied to toxicology.

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  • 1Tissue Informatics Inc, 711 Bingham Street, Suite 200, Pittsburgh, PA 15203, USA. akriete@tissueinformatics.com


We have developed a unique methodology for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology. This hybrid technology, termed extensible morphometric relational gene-expression analysis (EMeRGE), is applied in a toxicological study of time-varied vehicle- and carbon-tetrachloride (CCl4)-treated rats, and demonstrates correlations between specific genes and tissue structures that can augment interpretation of biological observations and diagnosis.

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