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Hua Xi Yi Ke Da Xue Xue Bao. 2001 Mar;32(1):129-30, 139.

[Study on bolus cyclosphamide treatment for 64 cases of lupus nephritis].

[Article in Chinese]

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  • 1Department of Clinical Immunology, First Affiliated Hospital, WCUMS, Chengdu 610041, China.

Abstract

OBJECTIVE:

To report on the dosing, efficacy and side-effects of bolus cyclosphamide treatment for lupus nephritis (LN).

METHODS:

64 consecutive cases of LN with 10 or more erythrocytes per high-power field, proteinuria (> 1 g of protein per day) and serum creatinine increased (> 133 mumol/L) were treated by bolus therapy with cyclophosphamide (CTX) given monthly for 6 months and then quarterly for 18 months.

RESULTS:

49 patients had renal remission (defined as < 10 erythrocytes per high-power field, absence of cellular casts, excretion of < 1 g of protein per day and normal serum creatinine). The mean of doses was 1.1 g for each time (0.6-1.6 g), the mean of times of bolus CTX needed was 3.6 (1-8 times). The adverse events were amenorrhea (in 41% female patients), herpes zoster (in 13% patients) and hemorrhagic cystitis (in 1 patient).

CONCLUSION:

The results indicate that monthly bolus CTX therapy is effective and safe for patients with LN. Its adverse effect is relatively not a serious problem.

PMID:
12733378
[PubMed - indexed for MEDLINE]
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