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Circulation. 2003 May 13;107(18):2290-3. Epub 2003 May 5.

In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction.

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  • 1Johns Hopkins University, School of Medicine, Department of Radiology, 601 N Caroline St, Suite 4231, Baltimore, Md 21287-0845, USA. dara@mri.jhu.edu

Abstract

BACKGROUND:

We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model.

METHODS AND RESULTS:

Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16x107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals.

CONCLUSIONS:

MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.

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