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Curr Opin Microbiol. 2003 Apr;6(2):198-201.

The top genes: on the distance from transcript to function in yeast glycolysis.

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  • 1Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.


With its abundant components and extensive study, the glycolytic pathway in the yeast Saccharomyces cerevisiae would appear ideal to obtain and reconcile the 'omes of transcript, protein, metabolite and flux. But to do so is challenging and, as is often the case, close correlation of gene expression and function is elusive, even in this organism.

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