J Nutr. 2003 May;133(5 Suppl 1):1468S-72S.

Iron deficiency alters brain development and functioning.

Source

Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802, USA. its@psu.edu

Abstract

Iron deficiency anemia in early life is related to altered behavioral and neural development. Studies in human infants suggest that this is an irreversible effect that may be related to changes in chemistry of neurotransmitters, organization and morphology of neuronal networks, and neurobiology of myelination. The acquisition of iron by the brain is an age-related and brain-region-dependent process with tightly controlled rates of movement of iron across the blood-brain barrier. Dopamine receptors and transporters are altered as are behaviors related to this neurotransmitter. The growing body of evidence suggests that brain iron deficiency in early life has multiple consequences in neurochemistry and neurobiology.

PMID:: 12730445; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Iron

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Iron - MedlinePlus Health Information

Molecular Biology Databases

IRON - HSDB

Supplemental Content

Save items

Related citations in PubMed

Review Why iron deficiency is important in infant development. [J Nutr. 2008]
Review Why iron deficiency is important in infant development.
Beard JL. J Nutr. 2008 Dec; 138(12):2534-6.
Minimal brain damage induced by early iron deficiency: modified dopaminergic neurotransmission. [Isr J Med Sci. 1987]
Minimal brain damage induced by early iron deficiency: modified dopaminergic neurotransmission.
Youdim MB, Ben-Shachar D. Isr J Med Sci. 1987 Jan-Feb; 23(1-2):19-25.
Review Iron status and neural functioning. [Annu Rev Nutr. 2003]
Review Iron status and neural functioning.
Beard JL, Connor JR. Annu Rev Nutr. 2003; 23:41-58. Epub 2003 Apr 10.
Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior. [Am J Clin Nutr. 1989]
Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior.
Youdim MB, Ben-Shachar D, Yehuda S. Am J Clin Nutr. 1989 Sep; 50(3 Suppl):607-15; discussion 615-7.
Recent evidence from human and animal studies regarding iron status and infant development. [J Nutr. 2007]
Recent evidence from human and animal studies regarding iron status and infant development.
Beard J. J Nutr. 2007 Feb; 137(2):524S-530S.

See reviews... See all...

Cited by 21 PubMed Central articles

Serum cholesterol and nigrostriatal r2* values in Parkinson's disease. [PLoS One. 2012]
Serum cholesterol and nigrostriatal r2* values in Parkinson's disease.
Du G, Lewis MM, Shaffer ML, Chen H, Yang QX, Mailman RB, Huang X. PLoS One. 2012; 7(4):e35397. Epub 2012 Apr 17.
Identifying a window of vulnerability during fetal development in a maternal iron restriction model. [PLoS One. 2011]
Identifying a window of vulnerability during fetal development in a maternal iron restriction model.
Mihaila C, Schramm J, Strathmann FG, Lee DL, Gelein RM, Luebke AE, Mayer-Pröschel M. PLoS One. 2011 Mar 15; 6(3):e17483. Epub 2011 Mar 15.
Motor development in 9-month-old infants in relation to cultural differences and iron status. [Dev Psychobiol. 2011]
Motor development in 9-month-old infants in relation to cultural differences and iron status.
Angulo-Barroso RM, Schapiro L, Liang W, Rodrigues O, Shafir T, Kaciroti N, Jacobson SW, Lozoff B. Dev Psychobiol. 2011 Mar; 53(2):196-210. Epub 2010 Oct 28.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Iron deficiency alters brain development and functioning.
Iron deficiency alters brain development and functioning.
J Nutr. 2003 May ;133(5 Suppl 1):1468S-72S.

PubMed
Concentrations of choline-containing compounds and betaine in common foods.
Concentrations of choline-containing compounds and betaine in common foods.
J Nutr. 2003 May ;133(5):1302-7.

PubMed
A geriatric survey in general practice.
A geriatric survey in general practice.
Practitioner. 1976 Apr ;216(1294):443-7.

PubMed
Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpress...
Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1.
J Lipid Res. 2003 Aug ;44(8):1470-80. Epub 2003 May 1 .

PubMed
The Vid vesicle to vacuole trafficking event requires components of the SNARE me...
The Vid vesicle to vacuole trafficking event requires components of the SNARE membrane fusion machinery.
J Biol Chem. 2003 Jul 11 ;278(28):25688-99. Epub 2003 May 2 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: