Annu Rev Biomed Eng. 2003;5:251-84. Epub 2003 Apr 18.

Multiaxial mechanical behavior of biological materials.

Source

Engineered Tissue Mechanics Laboratory, McGowan Institute for Regenerative Medicine and the Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. msacks@pitt.edu

Abstract

For native and engineered biological tissues, there exist many physiological, surgical, and medical device applications where multiaxial material characterization and modeling is required. Because biological tissues and many biocompatible elastomers are incompressible, planar biaxial testing allows for a two-dimensional (2-D) stress-state that can be used to fully characterize their three-dimensional (3-D) mechanical properties. Biological tissues exhibit complex mechanical behaviors not easily accounted for in classic elastomeric constitutive models. Accounting for these behaviors by careful experimental evaluation and formulation of constitutive models continues to be a challenging area in biomechanical modeling and simulation. The focus of this review is to describe the application of multiaxial testing techniques to soft tissues and their relation to modern biomechanical constitutive theories.

PMID:: 12730082; [PubMed - indexed for MEDLINE]

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