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1: Curr Diab Rep. 2003 Apr;3(2):151-8.Links

The genetics of adiponectin.

Vasseur F, Leprêtre F, Lacquemant C, Froguel P.

CNRS UMR 8090, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue du Docteur Calmette, BP 447, F-59021 Lille, France.

Adiponectin encoded by the APMI gene is one of the adipocyte-expressed proteins that function in the homeostatic control of glucose, lipid, and energy metabolism. Its dysregulation has been suggested to be involved in disorders covering the metabolic X syndrome, such as insulin resistance, obesity, type 2 diabetes, and coronary artery disease. Recent data present evidence of a genetic modulation of the adiponectin level, and linkage of the 3q27 locus, where the APMI gene lies, with diabetes and features of the metabolic X syndrome playing a putative role of the APMI gene in this syndrome. In this article, we present an overview of the results available to date and discuss positive evidence for a role of genetic variants of the APMI gene and questions that genetic data raise.

PMID: 12728641 [PubMed - indexed for MEDLINE]

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