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Fa Yi Xue Za Zhi. 2003;19(1):10-2.

[A analysis of ELISA on the time-related expression of IL-2 and TNF-alpha during the healing process of wound in rat skin].

[Article in Chinese]

Author information

  • 1Department of Pathology, First Military Medical University, Guangzhou 510515.

Abstract

OBJECTIVE:

In order to explore the relationship between the expression change of cytokines and the wound age during the healing process of rats skin wound.

METHODS:

A assay of ELISA were performed on intravital skin wounds(after incision 0.5-168 h) to detect the dynamics expression level of IL-2, TNF-alpha.

RESULTS:

The level of IL-2 and TNF-alpha increased at 0.5 h after wounding, then got to a peak at 3 h and 1 h after injure respectively. Rebound of TNF and IL-2 levels were shown at 48 h after wounding, and both cytokine levels were inclined to elevating between 72 h and 168 h after wounding.

CONCLUSION:

The cytokine level changes suggest they have a time-related expression during wounds healing process.

PMID:
12725158
[PubMed - indexed for MEDLINE]
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