Twin Res. 2003 Apr;6(2):83-4.

A case-control study of vanishing twin as a risk factor for cerebral palsy.

Newton R, Casabonne D, Johnson A, Pharoah P.

Source

Epidemiology Unit, Gibson Building, Radcliffe Infirmary, Oxford, OX2 6HE, UK. Rob.Newton@cancer.org.uk

Abstract

It has been hypothesized that cerebral palsy of unknown etiology is the result of the death of an unrecognized co-twin--a vanishing twin--in early gestation. We conducted a case-control study of vanishing twin as a risk factor for cerebral palsy of unknown etiology in women who had an obstetric ultrasound during pregnancy. Among mothers of cases, one of 86 had evidence of a vanishing twin on ultrasound, as compared to two of 381 control mothers (odds ratio [OR] 2.2, 95% confidence interval [CI] 0.2-24.8; p = 0.5). Bleeding in early pregnancy, which may indicate the loss of a co-twin, was reported by 14 case mothers and 46 control mothers (OR 1.6, 95% CI 0.8-3.0; p = 0.3). On the basis of results presented here, the vanishing twin syndrome is unlikely to account for a high proportion of cases of cerebral palsy, but there is insufficient statistical power to draw firm conclusions.

PMID:: 12723993; [PubMed - indexed for MEDLINE]

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