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Curr Opin Chem Biol. 2003 Apr;7(2):238-51.

Missing genes in metabolic pathways: a comparative genomics approach.

Author information

  • 1Integrated Genomics, Inc., 2201 W. Campbell Park Drive, Chicago, IL 60612, USA. andrei@integreatedgenomics.com

Abstract

The new techniques of genome context analysis--chromosomal gene clustering, protein fusions, occurrence profiles and shared regulatory sites--infer functional coupling between genes. In combination with metabolic reconstructions, these techniques can dramatically accelerate the pace of gene discovery.

PMID:
12714058
[PubMed - indexed for MEDLINE]
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