Department of Biopharmaceutical Sciences, University of California, 513 Parnassus Street, San Francisco, CA 94143-0446, USA. babbitt@cgl.ucsf.edu
Questions are being asked about how enzyme function is described at the molecular level and the strengths and weaknesses of the EC system for this purpose. A new approach to describing enzyme function has been proposed that might improve our capabilities for functional inference for members of enzyme superfamilies.