J Med Chem. 1976 May;19(5):615-9.

Direct measurement of octanol-water partition coefficients by high-pressure liquid chromatography.

Mirrlees MS, Moulton SJ, Murphy CT, Taylor PJ.

Abstract

A technique is presented for the direct measurement of octanol-water partition coefficients by HPLC. The method involves running solutes in octanol-saturated water as the mobile phase against water-saturated octanol entrained on an inert support. Log P correlates linearly with log tc for a number of standards. The measurable range in log P (so far) is -0.3 to +3.7. A critical review of chromatographic methods in Hansch analysis is given.

PMID:: 1271403; [PubMed - indexed for MEDLINE]

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Direct measurement of octanol-water partition coefficients by high-pressure liquid chromatography.

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Cited by 2 PubMed Central articles

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