In this study the authors investigated myeloperoxidase release from peripheral blood neutrophils isolated from patients with allergic respiratory tract diseases and from healthy subjects, induced by selected extrinsic allergens. We have observed the same degree of myeloperoxidase release from neutrophils isolated from both patients with allergic respiratory tract diseases and healthy subjects after stimulation by selected allergens (Dermatophagoides pteronyssinus, Grass mix). Moreover, control allergens (to which allergic persons were not sensitized) also caused myeloperoxidase release from neutrophils isolated from patients with allergic diseases of the airways. The authors suggest that recently postulated hypothesis concerning participation of neutrophil in the pathogenesis of allergic reactions as the alternative target cell cannot be accepted in the light of these observations.