Eur Psychiatry. 2003 Mar;18(2):77-81.

Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene.

Source

Department of Psychiatry, Medical Faculty of Gaziantep University, City, Gaziantep, Turkey. hasanherken@hotmail.com

Abstract

BACKGROUND:

The pathophysiology of tardive dyskinesia (TD) is not completely understood.Aim. - To assess the relationship of TD with 5-HT2A receptor gene, serotonin transporter gene (5 HTT), and catechol-o-methyltransferase (COMT) gene polymorphisms.

METHOD:

Our study comprised 111 unrelated subjects who strictly met DSM-IV criteria for schizophrenia and 32 TD, and 79 healthy unrelated controls; all the subjects were of Turkish origin. The analyses of 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were performed using polymerase chain reaction (PCR) technique.

RESULTS:

The polymorphisms of these genes were not significantly different between the schizophrenic patients, TD and control subjects.

CONCLUSION:

Our findings indicated that 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were similar in schizophrenia with non-TD, schizophrenia with TD, and healthy controls. These polymorphisms, though, do not help to evaluate the susceptibility to TD.

PMID:: 12711403; [PubMed - indexed for MEDLINE]

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