Lung Cancer. 2003 May;40(2):111-21.

Dissecting the genetic alterations involved in lung carcinogenesis.

Source

Molecular Pathology Program, Spanish National Cancer Center, C/ Melchor Fernández Almagro 3, 28029 Madrid, Spain. msanchez@cnio.es

Abstract

During the past two decades, considerable efforts have been devoted to the identification of the genes that drive lung cancer development. In spite of such intense research, only a few genes harboring mutations have been found, thus hindering the improvement in lung cancer treatment. The present review describes the catalog of known genetic alterations and the recent advances in global expression profiles in lung tumors and briefly discusses their use in clinical management.

PMID:: 12711111; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Lung Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review Cell cycle alterations and lung cancer. [Histol Histopathol. 2006]
Review Cell cycle alterations and lung cancer.
Vincenzi B, Schiavon G, Silletta M, Santini D, Perrone G, Di Marino M, Angeletti S, Baldi A, Tonini G. Histol Histopathol. 2006 Apr; 21(4):423-35.
Review Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. [Oncogene. 2002]
Review Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
Osada H, Takahashi T. Oncogene. 2002 Oct 21; 21(48):7421-34.
Review Molecular events in lung cancer. [Lung Cancer. 1995]
Review Molecular events in lung cancer.
Roth JA. Lung Cancer. 1995 Jun; 12 Suppl 2:S3-15.
Identification of genes involved in squamous cell carcinoma of the lung using synchronized data from DNA copy number and transcript expression profiling analysis. [Lung Cancer. 2008]
Identification of genes involved in squamous cell carcinoma of the lung using synchronized data from DNA copy number and transcript expression profiling analysis.
Lo KC, Stein LC, Panzarella JA, Cowell JK, Hawthorn L. Lung Cancer. 2008 Mar; 59(3):315-31. Epub 2007 Oct 29.
Review [Oncogenes and tumor suppressor genes in the pathogenesis of lung tumors]. [Pathologe. 1994]
Review [Oncogenes and tumor suppressor genes in the pathogenesis of lung tumors].
Wiethege T, Voss B, Müller KM. Pathologe. 1994 Dec; 15(6):321-30.

See reviews... See all...

Cited by 4 PubMed Central articles

The effect of adenovirus-mediated gene expression of FHIT in small cell lung cancer cells. [Cancer Invest. 2011]
The effect of adenovirus-mediated gene expression of FHIT in small cell lung cancer cells.
Zandi R, Xu K, Poulsen HS, Roth JA, Ji L. Cancer Invest. 2011 Dec; 29(10):683-91.
Impact on disease development, genomic location and biological function of copy number alterations in non-small cell lung cancer. [PLoS One. 2011]
Impact on disease development, genomic location and biological function of copy number alterations in non-small cell lung cancer.
Huang YT, Lin X, Chirieac LR, McGovern R, Wain JC, Heist RS, Skaug V, Zienolddiny S, Haugen A, Su L, et al. PLoS One. 2011; 6(8):e22961. Epub 2011 Aug 2.
A gene-alteration profile of human lung cancer cell lines. [Hum Mutat. 2009]
A gene-alteration profile of human lung cancer cell lines.
Blanco R, Iwakawa R, Tang M, Kohno T, Angulo B, Pio R, Montuenga LM, Minna JD, Yokota J, Sanchez-Cespedes M. Hum Mutat. 2009 Aug; 30(8):1199-206.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Dissecting the genetic alterations involved in lung carcinogenesis.
Dissecting the genetic alterations involved in lung carcinogenesis.
Lung Cancer. 2003 May ;40(2):111-21.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: