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Antimicrob Agents Chemother. 2003 May;47(5):1766-70.

Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration.

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  • 1Centre for Pharmaceutical Research. School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, Adelaide, Australia.


The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.

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