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Biol Psychiatry. 2003 Apr 15;53(8):691-700.

Acceleration and augmentation strategies for treating bipolar depression.

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  • 1Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA.


Despite the prevalence and morbidity of bipolar depression, few randomized treatment trials have been conducted to assess clinical efficacy. Even fewer studies have assessed approaches that optimize treatment response for bipolar depression. This review will define three types of common combination strategies--adjunctive, acceleration and augmentation--and discuss the limited literature of controlled studies reported on acceleration and augmentation approaches.

Copyright 2003 Society of Biological Psychiatry

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