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Mol Biochem Parasitol. 2003 Apr 25;128(1):59-65.

Characterization of PfRhop148, a novel rhoptry protein of Plasmodium falciparum.

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  • 1Department of Molecular Parasitology, The Lindsley Kimball Research Institute, New York Blood Center, 310 E 67th St, New York, NY 10021, USA. cheryl_lobo@nybc.org

Abstract

Rhoptries are apical organelles which play an important role in erythrocytic invasion. A Plasmodium falciparum cDNA clone, coding for a novel rhoptry protein PfRhop148, was obtained by antibody screening of a library. The deduced amino acid sequence consists of 1262 amino acids and is highly rich in Asn (22%). The Asn residues are distributed in clusters and in multiple units of repeats. Analysis of specific RNA transcript and protein showed that PfRhop148 was synthesized at around 21 h post-invasion. IFA and immunoelectron microscopic analyses revealed a rhoptry localization for the protein. The role of this protein in invasion and its relationship to the RhopH complex is now under further investigation.

PMID:
12706797
[PubMed - indexed for MEDLINE]
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