Modifications of histone cores and tails in V(D)J recombination

Genome Biol. 2003;4(4):211. doi: 10.1186/gb-2003-4-4-211. Epub 2003 Mar 31.

Abstract

The organization of chromatin and modifications to the tails of histone proteins are thought to be important in regulating the rearrangement of V, D and J gene segments, which encode immunoglobulins and T-cell receptors. A recent study shows that methylated lysine 79 in the core region of histone H3 also plays a role by providing a euchromatic 'mark' that may regulate access of the V(D)J recombinase.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromatin / genetics
  • Chromatin / metabolism
  • Gene Rearrangement, B-Lymphocyte*
  • Gene Rearrangement, T-Lymphocyte*
  • Histones / chemistry
  • Histones / metabolism*
  • Immunoglobulin Fragments / genetics*
  • Immunoglobulin Joining Region / genetics
  • Immunoglobulin Variable Region / genetics
  • Methylation
  • Mice
  • Recombination, Genetic

Substances

  • Chromatin
  • Histones
  • Immunoglobulin Fragments
  • Immunoglobulin Joining Region
  • Immunoglobulin Variable Region