Abstract
The organization of chromatin and modifications to the tails of histone proteins are thought to be important in regulating the rearrangement of V, D and J gene segments, which encode immunoglobulins and T-cell receptors. A recent study shows that methylated lysine 79 in the core region of histone H3 also plays a role by providing a euchromatic 'mark' that may regulate access of the V(D)J recombinase.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Chromatin / genetics
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Chromatin / metabolism
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Gene Rearrangement, B-Lymphocyte*
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Gene Rearrangement, T-Lymphocyte*
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Histones / chemistry
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Histones / metabolism*
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Immunoglobulin Fragments / genetics*
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Immunoglobulin Joining Region / genetics
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Immunoglobulin Variable Region / genetics
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Methylation
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Mice
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Recombination, Genetic
Substances
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Chromatin
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Histones
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Immunoglobulin Fragments
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Immunoglobulin Joining Region
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Immunoglobulin Variable Region