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Front Biosci. 2003 May 1;8:d855-69.

Function of bone morphogenetic protein signaling during mouse development.

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  • 1Molecular Developmental Biology Section, Laboratory of Reproductive and Developmental Toxycology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA.


Bone morphogenetic proteins (BMPs) play pleiotropic roles during development and after birth in many different organisms. BMPs are members of TGF-beta superfamily. There are more than 20 members with three type II receptors and three type I receptors. Genetic approaches using the mouse as a model system revealed many of the functions of BMPs. Particularly, results obtained through loss-of-function analyses of BMP ligands and their receptors are reviewed in this article.

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