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Front Biosci. 2003 May 1;8:d855-69.

Function of bone morphogenetic protein signaling during mouse development.

Author information

  • 1Molecular Developmental Biology Section, Laboratory of Reproductive and Developmental Toxycology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA. mishina@niehs.nih.gov

Abstract

Bone morphogenetic proteins (BMPs) play pleiotropic roles during development and after birth in many different organisms. BMPs are members of TGF-beta superfamily. There are more than 20 members with three type II receptors and three type I receptors. Genetic approaches using the mouse as a model system revealed many of the functions of BMPs. Particularly, results obtained through loss-of-function analyses of BMP ligands and their receptors are reviewed in this article.

PMID:
12700086
[PubMed - indexed for MEDLINE]
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