Display Settings:


Send to:

Choose Destination
Front Biosci. 2003 May 1;8:d855-69.

Function of bone morphogenetic protein signaling during mouse development.

Author information

  • Molecular Developmental Biology Section, Laboratory of Reproductive and Developmental Toxycology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA. mishina@niehs.nih.gov


Bone morphogenetic proteins (BMPs) play pleiotropic roles during development and after birth in many different organisms. BMPs are members of TGF-beta superfamily. There are more than 20 members with three type II receptors and three type I receptors. Genetic approaches using the mouse as a model system revealed many of the functions of BMPs. Particularly, results obtained through loss-of-function analyses of BMP ligands and their receptors are reviewed in this article.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk