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Appl Microbiol Biotechnol. 2003 May;61(3):189-96. Epub 2003 Jan 14.

Aspergillus niger citric acid accumulation: do we understand this well working black box?

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  • 1Department of Microbiology and Biotechnology, Faculty of Sciences, University of Debrecen, P.O. Box 63, 4010, Debrecen, Hungary.


This Mini-Review summarizes the current knowledge on the biochemical and physiological events leading to massive citric acid accumulation by Aspergillus niger under industrially comparable conditions, thereby particularly emphasizing the roles of glycolytic flux and its control, excretion of citric acid from the mitochondria and the cytosol, and the critical fermentation variables. The potential of novel techniques for metabolic analysis and genomic approaches in understanding this fermentation is also discussed.

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