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Arch Gen Psychiatry. 2003 Apr;60(4):359-64.

DNA fragmentation decreased in schizophrenia but not bipolar disorder.

Author information

  • 1Laboratories for Structural Neuroscience, McLean Hospital, Belmont, MA 02478, USA. benesf@mclean.harvard.edu

Abstract

BACKGROUND:

Apoptosis is thought to play a role in neuronal pathology in schizophrenia and bipolar disorder.

METHODS:

To test this hypothesis, the Klenow method for in situ end-labeling of single-stranded DNA breaks was applied to anterior cingulate cortex from 18 healthy controls, 18 schizophrenic subjects, and 10 bipolar subjects.

RESULTS:

An unexpected reduction (71%) in Klenow-positive nuclei was found in schizophrenic but not in bipolar cortexes.

CONCLUSIONS:

To our knowledge to date, this is the first demonstration that there is much less DNA fragmentation in individuals with schizophrenia than in healthy controls and bipolar subjects, which raises a key question as to whether this alteration represents an adaptive or nonadaptive change in the regulation of intracellular signaling and mitochondrial oxidative pathways associated with apoptosis.

PMID:
12695312
[PubMed - indexed for MEDLINE]
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