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Trends Neurosci. 2003 Apr;26(4):193-8.

The Nogo-66 receptor: focusing myelin inhibition of axon regeneration.

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  • 1Departments of Neurology and Neurobiology, Yale University School of Medicine, PO Box 208018, New Haven, CT 06520, USA. stephen.strittmatter@yale.edu


CNS myelin inhibits axonal outgrowth in vitro and is one of several obstacles to functional recovery following spinal cord injury. Central to our current understanding of myelin-mediated inhibition are the membrane protein Nogo and the Nogo-66 receptor (NgR). New findings implicate NgR as a point of convergence in signal transduction for several myelin-associated inhibitors. Additional studies have identified a potential coreceptor for NgR as p75(NTR), and a second-messenger pathway involving RhoA that inhibits neurite elongation. Although these findings expand our understanding of the molecular determinants of adult CNS axonal regrowth, the physiological roles of myelin-associated inhibitors in the intact adult CNS remain ill-defined.

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