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All roads lead to ATF4.
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
Multiple intracellular stress pathways converge on a single event--phosphorylation of the translation initiation factor eIF2alpha and subsequent translational activation of the transcription factor ATF4. Exploring the consequences of this event has highlighted the ways in which stress is sensed and responded to via many distinct pathways.
PMID: 12689582 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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Methamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatum.
Jayanthi S, McCoy MT, Beauvais G, Ladenheim B, Gilmore K, Wood W 3rd, Becker K, Cadet JL.
PLoS One. 2009 Jun 30; 4(6):e6092. Epub 2009 Jun 30.
[PLoS One. 2009]
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ReviewEndoplasmic reticulum stress in disorders of myelinating cells.
Lin W, Popko B.
Nat Neurosci. 2009 Apr; 12(4):379-85. Epub 2009 Mar 15.
[Nat Neurosci. 2009]
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Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy.
Yu DH, Macdonald J, Liu G, Lee AS, Ly M, Davis T, Ke N, Zhou D, Wong-Staal F, Li QX.
PLoS One. 2008; 3(12):e3951. Epub 2008 Dec 16.
[PLoS One. 2008]
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