Abstract
A series of novel 5'-phthaloylnucleosides were synthesized via Mitsunobu reaction starting from AZT or 2'-deoxyadenosine and numerous phthalimides and their sulphur analogues-thioimides. Some of them showed significant anticancer activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Cell Division / drug effects
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Deoxyadenine Nucleotides / chemistry
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Drug Screening Assays, Antitumor
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Humans
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Imides / chemical synthesis
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Imides / chemistry
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Imides / pharmacology
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Nucleosides / chemical synthesis*
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Nucleosides / pharmacology*
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Phthalic Acids / chemistry*
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Phthalic Acids / pharmacology*
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Tumor Cells, Cultured
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Zidovudine / chemistry
Substances
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Antineoplastic Agents
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Deoxyadenine Nucleotides
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Imides
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Indicators and Reagents
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Nucleosides
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Phthalic Acids
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Zidovudine