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Acta Cytol. 2003 Mar-Apr;47(2):135-40.

Significance of histiocytes on otherwise-normal cervical smears from postmenopausal women. A retrospective study of 108 cases.

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  • 1Department of Pathology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA.

Abstract

OBJECTIVE:

To evaluate the significance of histiocytes on normal cervical smears from postmenopausal women and correlate them with endometrial pathology.

STUDY DESIGN:

Histiocytes were classified into three types. The clinical history was obtained from cytologic and surgical reports.

RESULTS:

Among 108 cervical smears, 13 had large, foamy histiocytes (type A), 88 had histiocytes resembling superficial endometrial stromal cells (type B), and 7 had variably sized histiocytes alone or in association with inflammatory or multinucleated cells (type C). Endometrial pathology was identified in 13 patients (12.0%): 4/13 with type A histiocytes (2 endometrial adenocarcinomas, 2 endometrial polyps), 8/88 with type B histiocytes (8 endometrial polyps) and 1/7 with type C histiocytes (endometrial polyp). Among 70 patients with no clinical indications for endometrial sampling except for the presence of histiocytes, 4 demonstrated endometrial pathology (all endometrial polyps). In contrast, endometrial pathology was identified in 9/38 with clinical indications for endometrial sampling. Among the 13 patients with endometrial pathology, 9 had a significant clinical history (sensitivity of 69.2%), and 4 had histiocytes as the only indication for endometrial biopsy (sensitivity of 30.8%).

CONCLUSION:

A significant clinical history is more predictive of endometrial pathology and outweighs the significance of histiocytes as an indication for endometrial biopsy.

PMID:
12685178
[PubMed - indexed for MEDLINE]
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