Arch Pathol Lab Med. 2003 Apr;127(4):e181-5.

A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature.

Tang SJ, Geevarghese S, Saab S, Martinez D, Van Herle A, Wallace WD, Cortina GR, Dry S, Busuttil RW.

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Division of Digestive Diseases, Department of Medicine, University of California, Los Angeles, USA. tangs@smh.toronto.on.ca

Abstract

A diagnosis of parathyroid hormone-related protein (PTH-rP)-secreting metastatic uterine epithelioid leiomyosarcoma was made in a 61-year-old woman with humoral hypercalcemia of malignancy. A primary uterine tumor had been removed 10 years previously, which had been associated with a short history of hypercalcemia. The original uterine tumor was diagnosed as a smooth muscle tumor of uncertain malignant potential. To the best of our knowledge, this is the first reported case of a PTH-rP-secreting uterine leiomyosarcoma. We demonstrate the dramatic changes in serum calcium, phosphorus, PTH, and PTH-rP levels after tumor resection. Extensive biochemical analysis and detailed immunohistochemical and ultrastructural characterization demonstrate several features of this tumor.

PMID:: 12683897; [PubMed - indexed for MEDLINE]

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A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature.

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