Abstract
Novel thiazolocarbazole derivatives 4 and 5 have been synthesized via the corresponding imino-1,2,3-dithiazoles 3. In vitro antitumor activity of these polyheterocyclic compounds was studied and the results show that 2-cyano derivatives exhibit a medium in vitro antiproliferative effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Carbazoles / chemical synthesis*
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Carbazoles / pharmacology*
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Cell Cycle / drug effects
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Cell Division / drug effects
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Drug Screening Assays, Antitumor
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Imines / chemical synthesis
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Inhibitory Concentration 50
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Leukemia L1210 / drug therapy
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Mice
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Structure-Activity Relationship
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Carbazoles
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Imines
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Thiazoles