Notch signaling in lymphopoiesis

Semin Immunol. 2003 Apr;15(2):69-79. doi: 10.1016/s1044-5323(03)00003-4.

Abstract

Notch signaling regulates many cell fate decisions during development of multi-cellular organisms. Signals initiated by Notch influence a wide variety of processes that include lineage specification, cell survival and proliferation, and border formation. During development of the immune system, Notch has been shown to influence the fate of both hematopoietic stem cells (HSCs) and committed progenitors. Notch appears to play an especially important role in the development of cells that mediate acquired immunity where Notch influences multiple aspects of T and B cell development. In this review, we will focus on the potential functions of Notch signaling during lymphoid development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • Cell Lineage
  • Humans
  • Lymphopoiesis*
  • Membrane Proteins / physiology*
  • Mice
  • Models, Immunological
  • Receptors, Notch
  • Signal Transduction
  • T-Lymphocytes / immunology
  • VDJ Recombinases / metabolism

Substances

  • Membrane Proteins
  • Receptors, Notch
  • VDJ Recombinases