FEBS Lett. 2003 Apr 10;540(1-3):77-80.

Interaction of Sedlin with chloride intracellular channel proteins.

Source

Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, PR China.

Abstract

Sedlin is an evolutionarily conserved protein encoded by the causative gene SEDL for spondyloepiphyseal dysplasia tarda. Nevertheless, how Sedlin mutations cause the disease remains unknown. Here, the intracellular chloride channel protein CLIC1 was shown to associate with Sedlin by yeast two-hybrid screening. Green fluorescence protein-CLIC1 readily co-immunoprecipitated with FLAG-Sedlin. In addition, both proteins colocalized extensively in cytoplasmic vesicular/reticular structures in COS-7 cells, suggesting their interaction at intracellular membranous organelles. Sedlin also associated with CLIC2 in yeast two-hybrid assays. The link between Sedlin and the intracellular chloride channels is the first step to understand their functional interplays.

PMID:: 12681486; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

TRAPPC2 Gene - Genetics Home Reference

Research Materials

Miscellaneous

NCI CPTC Antibody Characterization Program

Supplemental Content

Save items

Related citations in PubMed

Interaction of Sedlin with PAM14. [J Cell Biochem. 2010]
Interaction of Sedlin with PAM14.
Liu X, Wang Y, Zhu H, Zhang Q, Xing X, Wu B, Song L, Fan L. J Cell Biochem. 2010 Apr 15; 109(6):1129-33.
Biochemical consequences of sedlin mutations that cause spondyloepiphyseal dysplasia tarda. [Biochem J. 2009]
Biochemical consequences of sedlin mutations that cause spondyloepiphyseal dysplasia tarda.
Choi MY, Chan CC, Chan D, Luk KD, Cheah KS, Tanner JA. Biochem J. 2009 Sep 25; 423(2):233-42. Epub 2009 Sep 25.
SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1. [PLoS One. 2010]
SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1.
Jeyabalan J, Nesbit MA, Galvanovskis J, Callaghan R, Rorsman P, Thakker RV. PLoS One. 2010 May 14; 5(5):e10646. Epub 2010 May 14.
Review Membrane traffic fuses with cartilage development. [FEBS Lett. 2003]
Review Membrane traffic fuses with cartilage development.
Sacher M. FEBS Lett. 2003 Aug 28; 550(1-3):1-4.
Review Challenging accepted ion channel biology: p64 and the CLIC family of putative intracellular anion channel proteins (Review). [Mol Membr Biol. 2003]
Review Challenging accepted ion channel biology: p64 and the CLIC family of putative intracellular anion channel proteins (Review).
Ashley RH. Mol Membr Biol. 2003 Jan-Mar; 20(1):1-11.

See reviews... See all...

Cited by 2 PubMed Central articles

SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1. [PLoS One. 2010]
SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1.
Jeyabalan J, Nesbit MA, Galvanovskis J, Callaghan R, Rorsman P, Thakker RV. PLoS One. 2010 May 14; 5(5):e10646. Epub 2010 May 14.
Review The TRAPP complex: insights into its architecture and function. [Traffic. 2008]
Review The TRAPP complex: insights into its architecture and function.
Sacher M, Kim YG, Lavie A, Oh BH, Segev N. Traffic. 2008 Dec; 9(12):2032-42. Epub 2008 Oct 14.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
MedGen
Related information in MedGen
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Interaction of Sedlin with chloride intracellular channel proteins.
Interaction of Sedlin with chloride intracellular channel proteins.
FEBS Lett. 2003 Apr 10 ;540(1-3):77-80.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: