Microbes Infect. 2003 Mar;5(3):213-9.

Regulation of the generation and maintenance of T-cell memory: a direct, default pathway from effectors to memory cells.

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Trudeau Institute, PO Box 59, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA. sswain@northnet.org

Abstract

Memory T cells are derived directly from effector cells without need for additional antigen, TcR triggering or induced cytokines. A large fraction of effectors can become memory cells without division, supporting a default pathway with little further differentiation. This suggests that the same signals during infection/vaccination determine the extent and nature of both effector and memory cell development.

PMID:: 12681410; [PubMed - indexed for MEDLINE]

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