Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Br J Biomed Sci. 2003;60(1):39-51.

Screening for thrombophilia: a laboratory perspective.

Author information

  • 1UK NEQAS (Blood Coagulation), Rutledge Mews, 3 Southbourne Road, Sheffield, UK. ian@coageqa.org.uk

Abstract

The worldwide annual incidence of venous thrombosis is estimated at 1 in 1000 individuals, and associated pulmonary embolism represents a major cause of morbidity and mortality. Thrombophilia may be an inherited or acquired condition, with the former identified in approximately 25-30% of patients with thromboembolic disease. Recently published guidelines on thrombophilia testing recommend assays for protein C, protein S and antithrombin; a modified activated protein C resistance test (with factor V-deficient plasma); polymerase chain reaction for prothrombin G20201A, together with prothrombin time, activated partial thromboplastin time, thrombin clotting time and assays to detect antiphospholipid antibodies. This review highlights some of the issues that laboratories should consider when employing tests for the diagnosis of thrombophilia.

PMID:
12680634
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk