Trends Biotechnol. 2003 Apr;21(4):157-61.

Organ printing: computer-aided jet-based 3D tissue engineering.

Mironov V, Boland T, Trusk T, Forgacs G, Markwald RR.

Source

Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA. mironovv@musc.edu

Erratum in

Trends Biotechnol. 2004 Jun;22(6):265.

Abstract

Tissue engineering technology promises to solve the organ transplantation crisis. However, assembly of vascularized 3D soft organs remains a big challenge. Organ printing, which we define as computer-aided, jet-based 3D tissue-engineering of living human organs, offers a possible solution. Organ printing involves three sequential steps: pre-processing or development of "blueprints" for organs; processing or actual organ printing; and postprocessing or organ conditioning and accelerated organ maturation. A cell printer that can print gels, single cells and cell aggregates has been developed. Layer-by-layer sequentially placed and solidified thin layers of a thermo-reversible gel could serve as "printing paper". Combination of an engineering approach with the developmental biology concept of embryonic tissue fluidity enables the creation of a new rapid prototyping 3D organ printing technology, which will dramatically accelerate and optimize tissue and organ assembly.

PMID:: 12679063; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Cell and organ printing 2: fusion of cell aggregates in three-dimensional gels. [Anat Rec A Discov Mol Cell Evol Biol. 2003]
Cell and organ printing 2: fusion of cell aggregates in three-dimensional gels.
Boland T, Mironov V, Gutowska A, Roth EA, Markwald RR. Anat Rec A Discov Mol Cell Evol Biol. 2003 Jun; 272(2):497-502.
Review Computer-aided tissue engineering: overview, scope and challenges. [Biotechnol Appl Biochem. 2004]
Review Computer-aided tissue engineering: overview, scope and challenges.
Sun W, Darling A, Starly B, Nam J. Biotechnol Appl Biochem. 2004 Feb; 39(Pt 1):29-47.
Organ printing: promises and challenges. [Regen Med. 2008]
Organ printing: promises and challenges.
Mironov V, Kasyanov V, Drake C, Markwald RR. Regen Med. 2008 Jan; 3(1):93-103.
Review Organ printing: tissue spheroids as building blocks. [Biomaterials. 2009]
Review Organ printing: tissue spheroids as building blocks.
Mironov V, Visconti RP, Kasyanov V, Forgacs G, Drake CJ, Markwald RR. Biomaterials. 2009 Apr; 30(12):2164-74. Epub 2009 Jan 26.
Cell and organ printing 1: protein and cell printers. [Anat Rec A Discov Mol Cell Evol Biol. 2003]
Cell and organ printing 1: protein and cell printers.
Wilson WC Jr, Boland T. Anat Rec A Discov Mol Cell Evol Biol. 2003 Jun; 272(2):491-6.

See reviews... See all...

Cited by 19 PubMed Central articles

Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics. [Biomicrofluidics. 2011]
Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics.
Choudhury D, Mo X, Iliescu C, Tan LL, Tong WH, Yu H. Biomicrofluidics. 2011 Jun; 5(2):22203. Epub 2011 Jun 29.
Spray deposition of live cells throughout the electrospinning process produces nanofibrous three-dimensional tissue scaffolds. [Int J Nanomedicine. 2011]
Spray deposition of live cells throughout the electrospinning process produces nanofibrous three-dimensional tissue scaffolds.
Seil JT, Webster TJ. Int J Nanomedicine. 2011; 6:1095-9. Epub 2011 May 25.
A novel strategy for engineering vascularized grafts in vitro. [World J Stem Cells. 2010]
A novel strategy for engineering vascularized grafts in vitro.
Liu JC. World J Stem Cells. 2010 Aug 26; 2(4):93-6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Organ printing: computer-aided jet-based 3D tissue engineering.
Organ printing: computer-aided jet-based 3D tissue engineering.
Trends Biotechnol. 2003 Apr ;21(4):157-61.

PubMed
UNVEILING OF THE BUST OF HENRY FAIRFIELD OSBORN AT THE AMERICAN MUSEUM OF NATURA...
UNVEILING OF THE BUST OF HENRY FAIRFIELD OSBORN AT THE AMERICAN MUSEUM OF NATURAL HISTORY.
Science. 1942 May 8 ;95(2471):471-2.

PubMed
The Henry Fairfield Osborn Papers at the American Museum of Natural History.
The Henry Fairfield Osborn Papers at the American Museum of Natural History.
Mendel Newsl. 1980 Jun ;(18):8-13.

PubMed
UNVEILING OF THE BUST OF HENRY FAIRFIELD OSBORN AT THE AMERICAN MUSEUM OF NATURA...
UNVEILING OF THE BUST OF HENRY FAIRFIELD OSBORN AT THE AMERICAN MUSEUM OF NATURAL HISTORY.
Science. 1942 May 8 ;95(2471):470-1.

PubMed
Modified technique for the surgical treatment of congenital constriction bands o...
Modified technique for the surgical treatment of congenital constriction bands of the arms and legs of infants and children.
Orthopedics. 2006 May ;29(5):401-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: