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Cell. 2003 Apr 4;113(1):2-4.

A new role for Ran in ensuring precise duplication of chromosomal DNA.

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  • 1Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland.

Abstract

To prevent re-replication of DNA, the licensing of replication origins is inhibited in S phase and G2. New work by Yamaguchi et al. (in this issue of Cell) shows that the small GTPase Ran can directly inhibit licensing inside nuclei once CDKs are active late in the cell cycle.

PMID:
12679026
[PubMed - indexed for MEDLINE]
PMCID:
PMC3604807
Free PMC Article
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