Cancer Cell. 2003 Mar;3(3):199-200.

Wiring the angiogenic switch: Ras, Myc, and Thrombospondin-1.

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Department of Urology, RH Lurie Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA.

Abstract

The formation of a blood supply is critical for tumor growth and metastasis; however, understanding the relationship of cellular transformation to tumor angiogenesis has been limited by the multifactorial nature of both processes. In this issue of Cancer Cell, Watnick and colleagues use a genetically defined tumor model system to determine the link between ras, myc, and angiogenesis and identify Thrombospondin-1 as being the critical regulator of angiogenesis in this system (Watnick et al., 2003).

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Cancer Cell. 2003 Mar;3(3):219-31.

PMID:: 12676576; [PubMed - indexed for MEDLINE]

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