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Curr Biol. 2003 Apr 1;13(7):R261-3.

Somatic mutation: early cancer steps depend on tissue architecture.

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  • 1Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697-2525, USA.


Cells progress from a normal to a cancerous state by accumulating mutations. Recent mathematical studies show how the size of the cellular population in a local patch of tissue influences the spread of cancer-promoting mutations.

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