Urol Res. 2003 Jun;31(2):47-54. Epub 2003 Mar 27.

Characteristics of nanobacteria and their possible role in stone formation.

Kajander EO, Ciftcioglu N, Aho K, Garcia-Cuerpo E.

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Department of Biochemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland. olavi.kajander@uku.fi

Abstract

Kidney stone formation is a multifactorial disease in which the defence mechanisms and risk factors are imbalanced in favour of stone formation. We have proposed a novel infectious agent, mineral forming nanobacteria (NB), to be active nidi that attach to, invade and damage the urinary epithelium of collecting ducts and papilla forming the calcium phosphate center(s) found in most kidney stones. Stone formation may proceed in urine supersaturated with calcium phosphate, calcium oxalate and uric acid/urate under the influence of crystallization promoters and inhibitors. Our hypothesis underlines the role of active nidi: even supersaturated urine requires nidi for crystallization to appear.

PMID:: 12669155; [PubMed - indexed for MEDLINE]

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