Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Drug Discov. 2003 Apr;2(4):289-95.

Challenges for the oral delivery of macromolecules.

Author information

  • 1Emisphere Technologies Inc, 765 Old Saw Mill River Road Tarrytown, New York 10591, USA. mgoldberg@emisphere.com

Abstract

The rapid integration of new technologies by the pharmaceutical industry has resulted in numerous breakthroughs in the discovery, development and manufacturing of pharmaceutical products. In particular, the commercial-scale production of high-purity recombinant proteins has resulted in important additions to treatment options for many large therapeutic areas. In addition to proteins, other macromolecules, such as the animal-derived mucopolysaccharide heparins, have also seen dramatic growth as injectable pharmaceutical products. To date, macromolecules have been limited as therapeutics by the fact that they cannot be orally delivered. This article will address the current status and future possibilities of oral macromolecular drug delivery.

PMID:
12669028
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk