Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R113-23.

Roles of BRCA1 in DNA damage repair: a link between development and cancer.

Source

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 10/9N105, National Institutes of Health, Bethesda, MD 20892, USA. chuxiad@bdg10.niddk.nih.gov

Abstract

DNA damage causes devastating problems for developing organisms. Recent studies reveal that BRCA1 plays essential roles in homologous recombinational repair, non-homologous end joining, and nucleotide excision repair. BRCA1 mediates these functions by interaction with components of the DNA repair machinery and by regulating expression of genes that are involved in these DNA damage repair pathways. Consequently, the absence of BRCA1 results in accumulation of chromosome damage, cell cycle abnormalities and apoptosis, leading to developmental abnormalities and adult tumorigenesis. In this review, we discuss recent advances regarding our understanding of the functions of BRCA1 in DNA damage repair and cellular responses that link development and cancer.

PMID:: 12668603; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

BRCA1 Protein

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Miscellaneous

Mouse Genome Informatics (MGI)

Supplemental Content

Save items

Related citations in PubMed

Review BRCA1 and cell signaling. [Oncogene. 2000]
Review BRCA1 and cell signaling.
Wang Q, Zhang H, Fishel R, Greene MI. Oncogene. 2000 Dec 11; 19(53):6152-8.
Review Good timing in the cell cycle for precise DNA repair by BRCA1. [Cell Cycle. 2005]
Review Good timing in the cell cycle for precise DNA repair by BRCA1.
Durant ST, Nickoloff JA. Cell Cycle. 2005 Sep; 4(9):1216-22. Epub 2005 Sep 13.
Review The role of the BRCA1 tumor suppressor in DNA double-strand break repair. [Mol Cancer Res. 2005]
Review The role of the BRCA1 tumor suppressor in DNA double-strand break repair.
Zhang J, Powell SN. Mol Cancer Res. 2005 Oct; 3(10):531-9.
Review BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. [Nucleic Acids Res. 2006]
Review BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution.
Deng CX. Nucleic Acids Res. 2006; 34(5):1416-26. Epub 2006 Mar 6.
Review The relationship between the roles of BRCA genes in DNA repair and cancer predisposition. [Trends Mol Med. 2002]
Review The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.
Tutt A, Ashworth A. Trends Mol Med. 2002 Dec; 8(12):571-6.

See reviews... See all...

Cited by 19 PubMed Central articles

Review The DNA damage response: Balancing the scale between cancer and ageing. [Aging (Albany NY). 2010]
Review The DNA damage response: Balancing the scale between cancer and ageing.
Seviour EG, Lin SY. Aging (Albany NY). 2010 Dec; 2(12):900-7.
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. [Proc Natl Acad Sci U S A. 2010]
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.
Reddy JP, Peddibhotla S, Bu W, Zhao J, Haricharan S, Du YC, Podsypanina K, Rosen JM, Donehower LA, Li Y. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3728-33. Epub 2010 Feb 3.
Modulatory effects of alpha- and gamma-tocopherols on 4-hydroxyestradiol induced oxidative stresses in MCF-10A breast epithelial cells. [Nutr Res Pract. 2009]
Modulatory effects of alpha- and gamma-tocopherols on 4-hydroxyestradiol induced oxidative stresses in MCF-10A breast epithelial cells.
Lee EJ, Oh SY, Kim MK, Ahn SH, Son BH, Sung MK. Nutr Res Pract. 2009 Fall; 3(3):185-91. Epub 2009 Sep 30.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Roles of BRCA1 in DNA damage repair: a link between development and cancer.
Roles of BRCA1 in DNA damage repair: a link between development and cancer.
Hum Mol Genet. 2003 Apr 1 ;12 Spec No 1:R113-23.

PubMed
American Heart Association/American College of Cardiology Foundation guide to wa...
American Heart Association/American College of Cardiology Foundation guide to warfarin therapy.
Circulation. 2003 Apr 1 ;107(12):1692-711.

PubMed
The occurrence of new mutants in the X-linked recessive Lesch-Nyhan disease.
The occurrence of new mutants in the X-linked recessive Lesch-Nyhan disease.
Am J Hum Genet. 1976 Mar ;28(2):123-37.

PubMed
Diffusional mobility of parvalbumin in spiny dendrites of cerebellar Purkinje ne...
Diffusional mobility of parvalbumin in spiny dendrites of cerebellar Purkinje neurons quantified by fluorescence recovery after photobleaching.
Biophys J. 2003 Apr ;84(4):2599-608.

PubMed
Finite element simulations of acetylcholine diffusion in neuromuscular junctions...
Finite element simulations of acetylcholine diffusion in neuromuscular junctions.
Biophys J. 2003 Apr ;84(4):2234-41.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: