Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Mol Cell. 2003 Mar;11(3):557-69.

The making of the mitotic chromosome: modern insights into classical questions.

Author information

  • 1Division of Gene Regulation and Expression, University of Dundee, DD1 5EH, Dundee, United Kingdom.


The condensation of mitotic chromosomes is essential for the faithful segregation of sister chromatids in anaphase. An emerging view is that chromosome assembly is an active and dynamic process of chromatin reorganization in which two ATP hydrolyzing enzymes, topoisomerase II and the condensin complex, play central roles. In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk