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Zhonghua Yi Xue Za Zhi. 2002 Dec 10;82(23):1622-4.

[Effect of local mild hypothermia on treatment of acute intracerebral hemorrhage, a clinical study].

[Article in Chinese]

Author information

  • 1Department of Neurology, First Affiliated Hospital of Harbin Medical University. Harbin 150001, China.

Abstract

OBJECTIVE:

To observe the effect of local mild hypothermia on treatment of acute intracerebral hemorrhage.

METHODS:

Forty patients with acute intracerebral hemorrhage were matched according to age and state of illness at a ratio of one to one and then randomly divided into two groups of 20 patients: routine group (dehydrant, antihypertensive agent, etc were given) and hypothermia group (in addition to the general treatment, controllable semiconductor brain-protecting freezer was used to produce local hyperthermia at temperature of 6 degrees C for 48 hours). Immediately after admission and one week and 2 weeks after treatment cranium CT was conducted and the volume of cerebral edema was calculated by Tada's formula.

RESULTS:

There was no significant difference in the volume of edema and scores according to European Stroke Scale between the two groups at admission (P > 0.05). The volumes of edema one week and 2 weeks after therapy were 17.4 +/- 6.2 and 13.1 +/- 5.8 milliliter respectively in hypothermia group, both significantly lower than those in the routine group (33.8 +/- 16.0 and 22.4 +/- 12.2 milliliter respectively, P < 0.05). The scores according to European Stroke Scale one week and 2 weeks after therapy were 62.1 +/- 10.8 and 70.3 +/- 10.7 in hypothermia group, both significantly higher than those in the routine group (52.8 +/- 10.9 and 60.5 +/- 10.9 respectively, P < 0.05). No side effect caused by local hyperthermia was observed during the therapy.

CONCLUSION:

A safe and reliable treatment, local mild hypothermia combined with routine therapy is effective in protecting the brain of patients with intracerebral hemorrhage.

PMID:
12667371
[PubMed - indexed for MEDLINE]
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