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Am J Infect Control. 2003 Apr;31(2):124-7.

High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux.

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  • 1Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, USA.

Abstract

BACKGROUND:

Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan.

METHODS:

Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (>1,000 microg/mL) triclosan resistance in P aeruginosa was assessed.

RESULTS:

The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1,000 microg/mL is solely attributable to the expression of efflux pumps.

PMID:
12665747
[PubMed - indexed for MEDLINE]
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