This paper describes the curriculum design and enhancements of dental gross anatomy courses at three universities in North America. The greatest problem for gross anatomy faculty is making the regions of the body below the neck relevant to dental students for their future clinical education as well as the longer term dental practice. The proposed solutions demonstrated in the three courses range from satisfying the student's grade and test requirements, such as passing the anatomical sciences section of the National Board Dental Examination Part I, to making the material relevant to clinical dentistry. Strategies to increase relevance include incorporating clinical faculty into the gross anatomy course and integrating dental clinical material into the course. Lastly, pedagogical innovations include peer teaching, the use of the Internet and intranet for examination preparation, and the animation of dental procedures to illustrate relevant anatomy to dentistry.