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Opt Lett. 2003 Jan 15;28(2):120-2.

Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design.

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  • 1Center for Devices and Radiological Health, Food and Drug Administration, 12725 Twinbrook Parkway, Rockville, Maryland 20857, USA.


Experimental verification of the ability to alter the sensitivity to fluorophore layers in turbid media by varying illumination-collection geometry is presented. Fiber-optic probes and two-layer, fluorophore-doped, turbid phantoms are used to elucidate the roles of spot size, illumination-collection fiber separation, and probe-sample spacing. Variations in single- and multiple-fiber probe design parameters produce significant changes in the relative sensitivity to sample layers in a manner that agrees with prior computational studies.

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