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Opt Lett. 2003 Jan 15;28(2):120-2.

Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design.

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  • 1Center for Devices and Radiological Health, Food and Drug Administration, 12725 Twinbrook Parkway, Rockville, Maryland 20857, USA. josh@eob.cdrh.fda.gov

Abstract

Experimental verification of the ability to alter the sensitivity to fluorophore layers in turbid media by varying illumination-collection geometry is presented. Fiber-optic probes and two-layer, fluorophore-doped, turbid phantoms are used to elucidate the roles of spot size, illumination-collection fiber separation, and probe-sample spacing. Variations in single- and multiple-fiber probe design parameters produce significant changes in the relative sensitivity to sample layers in a manner that agrees with prior computational studies.

PMID:
12656504
[PubMed - indexed for MEDLINE]
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