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1: J Antimicrob Chemother. 2003 Apr;51(4):1033-6. Epub 2003 Mar 13.Click here to read Links

Fusidic acid resistance in community isolates of methicillin-susceptible Staphylococcus aureus and fusidic acid prescribing.

Mason BW, Howard AJ, Magee JT.

Public Health Laboratory Service, Communicable Disease Surveillance Centre (Wales), Abton House, Wedal Road, Cardiff CF14 3QX, UK. Brendan.mason@phls.wales.nhs.uk

The level of resistance to fusidic acid among community methicillin-susceptible Staphylococcus aureus (MSSA) isolates in the UK and prescriptions for fusidic acid have both doubled over the past 6 years. It is hypothesized that selective pressure arising from topical use of fusidic acid in the community accounts for this increase. A significant correlation was found between prescribing of fusidic acid and resistance at the practice level (Spearman's rho = 0.46, 95% confidence interval 0.11-0.71, P = 0.01). Further controlled studies are required to determine whether this association is causal.

PMID: 12654748 [PubMed - indexed for MEDLINE]