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Antimicrob Agents Chemother. 2003 Apr;47(4):1449-51.

Trypanocidal and leishmanicidal properties of substitution-containing chalcones.

Author information

  • 1Faculdade de Farmácia, Centro de Ciências da Saúde, Universidade do Vale do Itajaí Departamento de Microbiologia e Parasitologia, Florianópolis, Santa Catarina, Brazil.

Abstract

Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of Leishmania braziliensis and Trypanosoma cruzi with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.

PMID:
12654691
[PubMed - indexed for MEDLINE]
PMCID:
PMC152493
Free PMC Article
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