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Arch Pathol Lab Med. 2003 Mar;127(3):e119-22.

Hepatosplenic alpha beta T-cell lymphoma: a report of an S100-positive case.

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  • 1Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.


Hepatosplenic T-cell lymphoma is an uncommon neoplasm characterized by a lymphoid infiltrate within the sinusoids of the liver, spleen, and bone marrow, without significant nodal involvement. The majority of cases express the gammadelta T-cell receptor and are associated with an isochromosome 7q cytogenetic abnormality. Recently, a small number of cases have been reported that express the alphabeta T-cell receptor. Here, we report our findings of a case of an S100-positive hepatosplenic alphabeta T-cell lymphoma in a 20-year-old woman who presented with pancytopenia and hepatosplenomegaly. The case adds to the growing literature of hepatosplenic alphabeta T-cell lymphomas.

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